IGFBP-3 contributes to cellular apoptosis in both IGF-dependent and -independent manners [6–12], although paradoxically, high IGFBP-3 mRNA and protein levels in breast tumors have been associated with aggressive forms of the disease [13–15], perhaps related to its ability to transactivate the EGF receptor [16], promote cell survival by autophagy [17], and contribute to the repair of DNA double-strand breaks [18]. Here, IGFBP3 is linked to breast neoplasm.