Also, we have demonstrated that loss of HSulf-1modulates the signaling of HS binding growth factors such as FGF-2, VEGF, HGF, and HB-EGF in ovarian [11], head and neck squamous carcinoma [11] and metastatic breast carcinomas [12] respectively and plays an important role in tumor progression, metastasis and angiogenesis [10, 13, 14]. Here, HBEGF is linked to neoplasm.