GADD45G and neoplasm: However, the average latency for tumor onset in the group with shRNA-mediated SIP1 inhibition and GADD45G induction (Tet+ GADD45G/shSIP1), was comparable to that in the groups without GADD45G expression, and much shorter than that in the group with GADD45G induction alone (Tet+ GADD45G/Vector ) (Figure 5A, 5B).