Our understanding of EGFR functions in cancer cells has expanded in recent years, e.g. from its function at the plasma membrane to the nucleus [27] and to the mitochondrion; [15, 28, 29] from its tyrosine kinase dependent functions to its tyrosine kinase independent functions; [30, 31] from its ligand-dependent functions to its ligand-independent function [8, 9]. The gene discussed is EGFR; the disease is cancer.