In a colon cancer animal model, overexpression of decoy receptor 3 led to enhanced tumor growth in association with an increase in M2 phenotypic macrophages/dendritic cells, which was abolished by antagonism of arginase 1, an inducer and marker of M2 macrophages/dendritic cells [38]. The gene discussed is TNFRSF6B; the disease is colonic neoplasm.