To understand the expanding role of the p65/miR-23a-27a-24 cluster in leukemia progression, cells from the acute promyelocytic leukemia cell line (APL) NB4 were treated with all-trans-retinoic acid (ATRA, 1mmol/L) for 3d to induce differentiation. The gene discussed is RELA; the disease is acute promyelocytic leukemia.