In contrast to a prior report on ELMO1, a regulator of GTPase activation and glioma cell motility [33], our study suggest that the crosstalk between the CD151-integrin complexes and RTKs converge at ARHGAP26, consistent with its link to the EGFR-mediated cell motility and signaling [48]. The gene discussed is ELMO1; the disease is central nervous system cancer.