False negativity that can be recognized in certain patient groups such as patients with leukemia, viral infections, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, ulcerative colitis, Sjögren’s syndrome, and cerebral infarction is an additional drawback for CRP as an acute phase marker [15]. The gene discussed is CRP; the disease is systemic lupus erythematosus.