The canonical pathway suggested to be affected for Bx T-cell lymphomas reflect the recurrent mutations in PTEN and MAP2K1; these two genes are mutated in 38% of all Bx T-cell lymphomas and not in a single Gr T-cell lymphoma or any of the B-cell lymphomas in this study (Table 2). Here, MAP2K1 is linked to B-cell non-Hodgkin lymphoma.