PKD1 and osteosarcoma: In addition, the detected SCNAs (Supplemental Fig. S4) show overlap with a few of the recurrently mutated genes, such as KLRK1, a member of the killer cell lectin-like receptor subfamily K, and PKD1, which encodes a polycystin protein involved in cell–cell/matrix interactions and with a role in cell migration and invasion in human osteosarcoma (Onishi et al. 2012).