POT1, the most significantly somatically mutated gene in the Gr and Cs B-cell lymphomas combined, encodes a protein important for telomere maintenance, and mutations in this gene predispose to several types of cancer in human (Robles-Espinoza et al. 2014; Shi et al. 2014). This evidence concerns the gene POT1 and B-cell non-Hodgkin lymphoma.