TRAF3 alone is mutated in 30%, and either or both TRAF3 and MAP3K14 are mutated in 50% of the cocker spaniel B-cell lymphomas and 30% of all golden retriever B-cell lymphomas—those two genes are also commonly seen mutated in human classical Hodgkin's lymphoma (Table 1; Otto et al. 2012). The gene discussed is TRAF3; the disease is B-cell non-Hodgkin lymphoma.