STAT3 and cancer: The canonical pathways identified for the two B-cell lymphoma data sets, when analyzed separately as well as together, include pathways for specific cancers, telomerase signaling pathways, and pathways associated with proliferation/apoptosis and autoimmune disorders, such as TWEAK signaling, APRIL-mediated signaling, and the STAT3 pathway (Table 3; Supplemental Table S4).