COX8A and cancer: In the T-cell lymphoma cohort, the most significantly mutated genes (Table 2) are SATB homeobox 1 (SATB1), followed by TBC1D26 (uncharacterized protein), proteasome subunit PSMA1, cytochrome c oxidase subunit VIIIA (COX8A), and tumor suppressor PTEN. About half of the most significantly mutated genes in this study have been implicated in human lymphoma, but there are also several hits that have not previously been reported in human cancer studies, such as genes from the NLRP family, with a role in innate immunity.