PTEN and T-cell non-Hodgkin lymphoma: PTEN antagonizes the PI3K-AKT-mTOR pathway (Maehama and Dixon 1998; for review, see Song et al. 2012; Worby and Dixon 2014), and at least one of those four genes are mutated in almost half (44%) of all Bx T-cell lymphomas but only in 6% of all Gr T-cell lymphomas (Table 2), suggesting that this pathway is highly important for Bx T-cell lymphoma development.