Although we had already found that KCNB1 rs1051295 genotype TT was associated with T2D and decreased insulin sensitivity in our previous study, no association was observed for rs1051295 and insulin resistance in either dominant model (P = 0.72, OR = 1.07 (0.75,1.51)) or recessive model (P = 0.24, OR = 0.75(0.47,1.20)) by univariate or multivariate analysis in this study. Here, INS is linked to type 2 diabetes mellitus.