Symptoms in those patients included wide-based gait, limb ataxia, dysarthria, loss of fine motor control and intention tremor; in one patient, who was also positive for CV2/CRMP5 and neuronal acetylcholine receptor (AChR) antibodies, ataxia was accompanied by dysphagia and constipation [35]. This evidence concerns the gene DPYSL5 and Ataxia.