SERPINE1 and ventilator-associated pneumonia: In our study, we found that the combination of TNFRI and GCSF achieved a very good sensitivity and specificity (sensitivity: 96 %, specificity: 87 % ) at the day of diagnosis of VAP and TNFRI and PAI-1 showed a moderate to good discrimination 3 days before the diagnosis (AUC 0.79).