In this regard, this is the first study showing that VEGF inhibition by D2-ag is specifically exerted at the post-transcriptional level with effect in of both peptide translation and subsequent releases once it has been produced, suggesting that D2-ag treatment should be combined with therapies to inhibit VEGF transcription, such as LH or GnRH agonists treatment for triggering ovulation, to improve the efficacy of OHSS prevention [6, 7]. Here, GNRH1 is linked to ovarian hyperstimulation syndrome.