APTX and Hypoalbuminemia: This leads to aprataxin (APTX), a deoxyribonucleic acid (DNA) repair protein, being prevented from entering the nucleus due to phosphorylation and, in consequence, to increased oxidative stress-induced DNA damage and cell death [41]; mutations in the APTX gene underlie early-onset ataxia with oculomotor apraxia and hypoalbuminaemia [44].