Of note, injection of polyclonal antibodies specific for the putative ligand-binding region of GluRδ2 generated by immunisation of rabbits with a synthetic peptide into the supracerebellar subarachnoid space was shown to cause AMPA receptor endocytosis, attenuate synaptic transmission and abrogate long-term depression in PC cultures and transient ataxia in mice [80]. This evidence concerns the gene GRID2 and Ataxia.