SCRIB and prostate intraepithelial neoplasia: We have previously shown that conditional homozygous deletion of Scrib mediated by Probasin- and MMTV-driven Cre-recombinase expression causes low-grade prostate intraepithelial neoplasia and mammary gland dysplasia respectively in mice, establishing that Scrib is a mammalian tumor suppressor gene [7, 30].