SCRIB and neoplasm: However, we did not observe any significant changes in the number of p-ERK positive nuclei in DMBA/TPA-induced size-matched benign papillomas from Scrib+/+, Scrib+/fl and Scribfl/fl (Additional file 3: Figure S3D and E), suggesting that the increased tumour phenotype observed upon deletion of Scrib is unlikely to reflect changes in Ras/MAPK signalling.