ALDOB and hepatocellular carcinoma: Similarly, of the 103 patients with TNM I stage HCC, 46 patients with ALDOB downregulation had a poorer surgical prognosis as compared to the remaining 57 patients (26.3 and 53.3 % versus14.0 and 26.3 % for the 1 and 3 year cumulative recurrence rates respectively; P = 0.0110; 82.6 and 56.5 % versus 96.5 and 86.0 % for the 1 and 3 year survival rates respectively; P = 0.0007) (Fig. 2e and f).