Microscopically, there was an abundance of ubiquitylated neuronal cytoplasmic inclusions as well as occasional ubiquitylated neurites throughout the CNS, but most prominently in the larger hindbrain neurons of gba1−/− fish at 12 wpf (Fig. 7H and I) which bear resemblance to Lewy bodies and Lewy neurites in postmortem PD brain tissue (Fig. 7J). Here, GBA1 is linked to Parkinson disease.