BAX and colorectal cancer: Finally, it has been described that I2 or 6IL induces apoptosis effects through at least two pathways: AIF/PARP1 and Bax-caspases [1, 9]; Bonofiglio et al. [51] reports that PPARG is able to activate the promoter of the FasL gene, thereby inducing extrinsic apoptosis in MCF-7 cells; this observation was reinforced recently by similar findings in human colorectal cancer cells [52].