Pre-treatment of wild-type mice with apocynin prior to CLP-sepsis surgery similarly abrogated the septic increases in pulmonary microvascular/PMVEC EB-albumin permeability, PMVEC death (PI+) and apoptosis (TUNEL+) (Fig. 6a, b, c), similar to the observations in septic NADPH oxidase-deficient mouse strains. Here, FMO5 is linked to Sepsis.