ANXA5 and Sepsis: There was a high degree of overlap between the 2 earliest markers of apoptosis (Annexin V binding and FLIVO staining) at 4 h after CLP-sepsis (Fig. 2): 100 ± 0 % of Annexin V+ PMVEC were also FLIVO+, and 93 ± 3 % of FLIVO+ PMVEC were Annexin V+.