In contrast, Q-VD treatment prior to CLP-sepsis surgery significantly attenuated septic pulmonary microvascular/PMVEC permeability barrier dysfunction (Fig. 4a) as well as septic increases in both PMVEC death (decreased PI+ staining; Fig. 4b) and specifically apoptosis as reflected by decreased presence of FLIVO, Annexin V, and TUNEL labeling (Fig. 4c and d). Here, ANXA5 is linked to Sepsis.