This feature of septic pulmonary microvascular dysfunction, specifically enhanced PMN sequestration, was significantly attenuated following: (a) inhibition of caspases with Q-VD pre-treatment of wild-type mice prior to induction of CLP-sepsis, (b) CLP-sepsis in gp91phox−/− and p47phox−/− mice, and (c) inhibition of NADPH oxidase with apocynin pre-treatment of wild-type mice prior to CLP-sepsis. The gene discussed is FMO5; the disease is Sepsis.