NOS2 and hyperinsulinemic hypoglycemia, familial, 4: Intriguingly, in the present study, reduced PMVEC death/apoptosis in response to various interventions (e.g. Q-VD caspase inhibition, NADPH oxidase deficiency/inhibition) was associated with reduced pulmonary microvascular PMN sequestration, similar to our previous findings in septic Nos2−/− mice [17, 37].