CD8A and acute hemorrhagic leukoencephalitis: Recently, Pirko et al. demonstrated the first murine model of AHLE by injecting the VP2121–130 viral capsid of the Theiler’s murine encephalomyelitis virus that induces a strong in vivo activation of CD8+ T cells in C57BL/6 mice leading to the development of hemorrhagic demyelination within 24 h [7].