TP53 and neoplasm: Similarly, in the MAPK, mTOR, p53, and Wnt signaling pathways, there were significantly more genes with orphan repeats (after Bonferroni correction, WRS test, P < 10−31, P < 10−24, P < 10−9, P < 10−18, respectively, see Fig. 4b) between tumor-normal genomes compared to normal genome pairs.