RB1 and colorectal cancer: For examples, miR-675 modulates human gastric cancer cell proliferation by targeting tumor suppressor Runt Domain Transcription Factor1 (RUNX1) [50];miR-675 was found to be upregulated in human colorectal cancer (CRC) tissues and the tumor suppressor retinoblastoma (RB) was confirmed to be a direct target of miR-675 [51].