The involvement of miR675 promotion of liver cancer cell growth is supported by results from four parallel sets of experiments: (1) The upregulated expression level of miR675, H19, HP1α, EGR1, PKM2, H-Ras were consistent in liver cancer patients ; miR675 promotes the liver cancer cells malignant proliferation in vitro and accelerates liver cancer growth in vivo. This evidence concerns the gene PKM and liver cancer.