Phosphatase and tensin homolog (PTEN), a tumor suppressor gene identified in 1997 [11-13], encodes a lipid and protein phosphatase that is involved in the regulation of a variety of signaling transduction pathways, including the PI3K/Akt pathway, which are critical in cell apoptosis, adhesion and mobility, as well as in the regulation of chromosomal stability [14-18]. Here, PTEN is linked to neoplasm.