Activation of Tyr 985 is required for triggering rat sarcoma (Ras)/rapidly accelerated fibrosarcoma (Raf)/extracellular signal-regulated kinases 1/2 (ERK1/2) pathways through interaction with an adaptor protein, growth factor receptor-bound protein 2 (GRB2) [47]. The gene discussed is GRB2; the disease is fibrosarcoma.