Furthermore, high folate intake was associated with reduced risk of ER+, PR+, ER+PR+ and HER2- subtypes; high thiamine was associated with reduced risk of ER-PR- and HER2+ disease; high riboflavin was associated with reduced risk of ER+, PR+, HER2+, and HER2- disease; and high vitamin B6 was associated with reduced risk of ER+, ER-, PR-, and HER2- cancers. Here, ESR1 is linked to cancer.