AFP and hepatocellular carcinoma: A previous study has also indicated that the PLT level is a predictor of portal vein invasion.64 In addition, a decreased PLT level has been significantly associated with an elevated AFP level54,65,66 and abnormal liver function.6 These findings may aid in the elucidation of the potential mechanism underlying the influence of the PLT level on HCC patient outcome, but more studies are needed to determine the exact mechanism.