Of interest, the peak RNA and nadir CD4% had different relationships with DMN connectivity in our PHIV+ youth (Figure 4), suggesting that a history of advanced immune suppression and higher peak HIV RNA levels may have varying effects on brain function.4 Although progression of HIV infection generally leads to a subsequent drop in CD4 cell count, CD4 count and HIV viral load do not always directly relate to one another. The gene discussed is CD4; the disease is HIV infectious disease.