Moreover, also MACROD2, PPP1R12B, AKAP13, ERGIC1, PTPRT, SLC22A5, HIST1H1A, ASNS, and ROCK1 breakpoint genes were represented in one of the gene modules, and contributed to CRC subtype classification (Fig 4 and S7 Table). This evidence concerns the gene MACROD2 and colorectal carcinoma.