At an individual gene level within the identified CRC subtype-associated genes, the poor prognostic CRC subtype 3 was a. o. enriched for gene point mutations in BRAF (two-sided Fisher Exact test: P<0.0001) and FBXW7 (P = 0.01), and for gene breakpoints in WWOX (P<0.0001), FHIT (P<0.0001), and PIBF1 (P = 0.03). The gene discussed is BRAF; the disease is colorectal carcinoma.