AFP and cirrhosis of liver: In addition, Kaplan-Meier analysis demonstrated that high Cripto-1 expression (P < 0.001), high AFP level (P = 0.001), high GGT level (P = 0.016), liver cirrhosis (P = 0.012), larger tumor size (P < 0.001), satellite nodule (P = 0.007) and vascular invasion (P < 0.001) were significantly associated with shorter TTR in HCC patients (Table 2).