The mammalian EGFR and components of the mammalian EGF signaling pathway are known to enhance glucose absorption in the gut [128], induce obesity in ovariectomized [129] and aged female mice [130], are decreased in adipose tissues of calorie restricted mice [131], and are associated with hyperglycemia in humans [132]. The gene discussed is EGFR; the disease is obesity due to melanocortin 4 receptor deficiency.