The mammalian orthologs of tws, protein phosphatase 2, regulatory subunit B, alpha and delta (PPP2R2A and PPP2R2D) [107] dephosphorylate FOXO1 to cause its nuclear import during the oxidative stress accompanying pancreatic β cell death of diabetes [171], associate with increased lipid levels upon high fat feeding [172], and are regulated by microRNA-136 in the aberrant proliferation of vascular smooth muscle cells that accompanies atherosclerosis [173]. The gene discussed is PPP2R2A; the disease is diabetes mellitus.