While tumor cells may secrete various stimulatory growth factors and cytokines such as TNF-α, IL-6, TGF-β, and IL-10 to avoid immunosurveillance and create a pro-tumorigenic environment, little is yet understood about how direct cell-cell communication between the tumor cells, rather than tumor-stroma interactions, influences malignancy. Here, TGFB1 is linked to neoplasm.