2A), suggesting different mechanisms underline tumorigenesis driven by H878Y and YVMA mutant HER2 in vivo. In addition, bitransgenic pups of all three H878Y founder lines had a medium survival below 10 weeks after Dox induction (Figure. 2B). Additionally, Immunoblotting of lung tissue lysates from tumor bearing transgenic mouse had been detected with activated HER2 downstream signals (Figure 2C), consistent with the result from in vitro cell lines. The gene discussed is ERBB2; the disease is neoplasm.