KCNA3 and neoplasm: For translation into regimens aimed to impair with the functions of tumor reactive stroma, class I (sodium-channel blockers, such as procainamide, mexiletine or flecainide), class III (potassium-channel blockers, such as amiodarone) or class IV (calcium-channel blockers, verapamil) drugs may be tested, based on our evidence that sodium, potassium and calcium voltage-gated channel are highly up-regulated in CAF vs HPFs (Supplementary Figure S1).