ANOS1 and non-acquired combined pituitary hormone deficiency: Our results, and that of a recently published finding which detected a missense KAL1 variant in a male with hypopituitarism, support the known overlap in genotypes between KS and congenital hypopituitarism (McCabe et al., 2011b, Raivio et al., 2012, Vaaralahti et al., 2012, McCabe et al., 2013, Takagi et al., 2014).