VAV3 and breast cancer: Fig 2 shows four such genes, (DLGAP5, KIF2C, ZMYND10, and VAV3), with their overexpression levels positively or negatively correlate with the breast-cancer grades. It is noteworthy that DLGAP5 has been found that its silencing suppresses tumorigenicity and inhibits cellular proliferation in cancer cells [16]. KIF2C has been reported that its overexpression involves in breast carcinogenesis [17]. ZMYND10 is a tumor suppressor gene in neuroblastoma [18]. VAV3 has been reported to serve as an oncogene and its overexpression is associated with poor prognosis of a breast cancer [19].