BHLHE40 and breast cancer: Fig 4 shows four such examples, (BHLHE40, HSD17B6, CACNA1A, HDAC8), each with either positive or negative correlation with the stage progression. Among them, BHLHE40 has been reported to correlate with the increased malignancy potential and invasiveness in breast cancer [22]. HSD17B6 is known to be a key enzyme that can catalyze the conversion of 3α-diol to DHT in prostate cancer [23]. CACNA1A is predicted to be a tumor suppressor gene in lung cancer [24]. HDAC8 has been reported to link to the dysregulated expression or interaction with transcription factors critical to tumorigenesis [25].