It has been also reported the role of decorin (a SLRP member protein) in extracellular matrix of liver fibrosis as inhibitor of TGF-β [45], the most powerful profibrotic cytokine, and studies suggest the presence of other SLPR members, such as CHAD, in attenuating TGF-β bioactivity [46–48]. This evidence concerns the gene CHAD and Hepatic fibrosis.