KMT2A and acute myeloid leukemia: The cooperative functions of MLL-PTD with FLT3-ITD mutations in the leukemogenesis of AML have been studied by Zorko et al, who demonstrated that the MllPTD/wt:Flt3ITD/wt double knock-in mice spontaneously developed AML and recapitulated the cytogenetic and molecular characteristics of human MLL-PTD and FLT3-ITD AML [25].