Of the six selected SNPs located in or near the genes FADS2 (rs174570), MAFB (rs6102059), HMGCR (rs3846663), MLXIPL (rs3812316), APOE/C1/C4/C2 (rs4420638) and CELSR2/PSRC1/SORT1 (rs599839), we observed a strong impact of rs599839 (SORT1) and rs4420638 (APOE) on circulating LDL-C levels independent of the degree of obesity in conventional linear regression analyses adjusting for age, sex and BMI SDS. This evidence concerns the gene FADS2 and obesity due to melanocortin 4 receptor deficiency.