Consistent with a recent report demonstrating that GR transcriptional outcomes are not determined by GRE types30, we show that Dex-liganded GR binds to the precisely defined GRE to both activate oncogenes (for example, BIRC3 and NEDD9) and repress tumour suppressor genes (for example, STK4) in TNBC cells (Figs 2, 3, 4). This evidence concerns the gene BIRC3 and neoplasm.