We therefore analysed gene expression profiles from pharmacotherapy-sensitive and -resistant breast cancer cell lines12 and found that high GR expression was correlated with resistance to the mammalian target of rapamycin inhibitor AZD8055, AKT inhibitor MK2206 and mitotic kinesin Eg5 inhibitor S-trityl-L-cysteine (Fig. 1a). This evidence concerns the gene NR3C1 and breast cancer.