Intriguingly, two of these are also among the 163 SNPs associated with risk of Crohn’s disease (rs102275 near FADS1 and rs780093 near GCKR; overlap of 0.0006 expected by chance for >3000-fold enrichment), and the directions of effect indicate high palmitoleic acid could be associated with increased disease risk. This evidence concerns the gene GCKR and Crohn disease.