Gene alterations in KIT, EGFR, BRAF, HRAS, KRAS, NRAS, PIK3CA, PDGFRA, and PTEN have been reported in adenoid cystic carcinoma (ACC) [4, 5, 7–16], but the results are inconsistent among different studies [10, 12, 17]. The gene discussed is PIK3CA; the disease is adrenal cortex carcinoma.