In conclusion, the genetic mutations associated with PACC are different from those implicated in non-small cell lung cancer, and EGFR, KRAS, BRAF, ALK, PIK3CA, PDGFRA, and DDR2 may not be driver genes in PACC; we must identify other genes for targeted therapy against PACC. This evidence concerns the gene PIK3CA and non-small cell lung carcinoma.