ADRB2 and pulmonary arterial hypertension: In the present study we noted CC genotype of rs1042714 to be beneficial at high altitude, however, in Kyrgyz highlanders, higher frequency of homozygous CC genotype of ADRB2 Gln27Glu (rs1042714:G > C) was reported to be associated with high altitude pulmonary hypertension [70].