Nevertheless, as ‘lifestyle diseases’ including hypertension are on the rise in Ladakh natives (www.reachladakh.com/archive_details.php?pID=2610 ), it may be worthwhile to survey the prevalence of high altitude pulmonary hypertension in Indian highlanders and correlate with ADRB2 Gln27Glu (rs1042714:G > C) frequency in a large cohort. Here, ADRB2 is linked to pulmonary hypertension.