To assess the efficacy of BMP ligands in selectively targeting endothelial BMPR2 signaling, Long and colleagues generated a BMPR2-deficient mouse PAH model and examined two rat PAH models in response to either monocrotaline or vascular endothelial growth factor receptor blockade and hypoxia (Sugen-hypoxia) (Long et al., 2015). The gene discussed is BMPR2; the disease is pulmonary arterial hypertension.