[14-18] According to the “normalization” hypothesis, bevacizumab instigates a redistribution of tumor blood flow, increasing the delivery of chemotherapy to the tumor.[21, 22] Another possible mechanism is treatment-related changes in VEGFA, although attempts to predict the effect of bevacizumab on tumor or plasma VEGFA levels have been largely inconsistent. The gene discussed is VEGFA; the disease is neoplasm.