Ten genes (ALDH1L1, BCL6, EPHB3, FGD5, FGF12, ITGA9, NUDT16P, RBSP3, WNT7A and ZIC4) were identified showing reduced signal in NPC samples as compared to control samples suggesting methylation or deletion of these genes in NPC (Table 1). The gene discussed is ZIC4; the disease is nasopharyngeal carcinoma.