In univariate analysis using continuous clinicopathological biomarkers, high CIN25 and CIN70 scores were associated with younger age (p < 0.0001), high tumour grade (p < 0.0001), PgR negativity (p < 0.0001) and ER negativity (p < 0.0001) but not with tumour size, nodal status or HER2 status. The gene discussed is PGR; the disease is neoplasm.