Moreover, global gene expression comparison in tumor tissues extracted from two nude mice i.p. injected with sh-B1 cells, versus tumors from two mice injected with Ctrl cells, displayed evident similarity between the major functionally related gene groups that were differentially expressed upon BCAT1 silencing both in vitro and in vivo (see Figure 5 and Supplemental Figure 5). This evidence concerns the gene BCAT1 and neoplasm.