However, Fessler et al found that the odds ratio of atopy defined as serum specific IgE positivity against allergens was OR = 1.17 (95% CI: 1.00, 1.38) per two standard deviation increase in total cholesterol which is comparable to ORs of serum cholesterol for myocardial infarction [14]. This evidence concerns the gene IGHE and myocardial infarction.