Of the established mammalian targets of RIDD, only Scara3 and Sparc were downregulated in both ColXN617K versus wildtype (S1 Table) and C/X versus Xbp1CartΔEx2 (S3 Table), suggesting that RIDD does not have a significant role in the pathology of MCDS. This evidence concerns the gene SPARC and Schmid metaphyseal chondrodysplasia.