COL10A1 and Schmid metaphyseal chondrodysplasia: We demonstrated in two mouse models of Schmid metaphyseal chondrodysplasia (MCDS), a condition involving dwarfism and growth plate hypertrophic zone expansion caused by autosomal dominant mutations in the hypertrophic zone marker collagen X (Col10a1), that hypertrophic zone ER stress per se is sufficient to phenocopy the disease [11].