From these results we suggest that down-regulation of RAS system by exercise training in hypertensive individuals occurs in several brain autonomic areas, but the reduced PVN Aogen availability seems to be the main effect to blunt hypertension-induced deficits in cardiovascular control driven by vasoconstrictor, trophic, pro-oxidative and pro-inflammatory effects of Ang II excess. The gene discussed is AGT; the disease is Hypertension.